DECIPHER IMAGES / FILMS AND PHOTOGRAPHY BY KAROL ORZECHOWSKI

MAXIMUM TOLERATED DOSE [trailer]

Trailer III:


TRAILER II:


TRAILER I:

SEE THE OFFICIAL MTD WEBSITE:

http://maximumtolerateddose.org

“A look inside modern animal experimentation
with the animals who lived through it
and the people who walked away.” 

Maximum Tolerated Dose (MTD): An animal / human experiment to find the highest dose of a chemical that, when administered to a group of test subjects in a clinical trial, does not result in a fatality due to short-term toxicity. This dose is then used for longer-term safety studies of the same species, lasting anywhere from two years to a lifetime. The MTD test is controversial, however, in part because of difficulties in extrapolating findings to more realistic doses, and in extrapolating results from animals to humans.

Maximum Tolerated Dose is the first feature-length documentary by Decipher Films. Equal parts found-footage mash-up, verité investigation, and artful meditation, the film charts the lives of both humans and non-humans who have experienced animal testing first-hand, with hauntingly honest testimony of scientists and lab technicians whose ethics demanded they choose a different path, as well as the simultaneously heartwarming and heartbreaking stories of animals who have seen both sides of the cage. MTD aims to re-ignite the debate about animal testing by bringing these rarely-heard perspectives to the fore.

Directed by Karol Orzechowski
Edited by Karol Orzechowski & Jonathan Eagan
Produced by Jonathan Hodgson, Jennifer Bundock & Karol Orzechowski
Additional Filming by Jo-Anne McArthur & Guna Subramaniam
With Selected Archival Footage from The BUAV & Igualdad Animal
Music by Wyrd Visions and Bryan W. Bray